Publications
*denotes corresponding author; †denotes equal contribution; names of the undergraduate student co-workers are underlined
*denotes corresponding author; †denotes equal contribution; names of the undergraduate student co-workers are underlined
1.) Activity-Based Sensing for Chemistry-Enabled Biology: Illuminating Principles, Probes, and Prospects for Boronate Reagents for Studying Hydrogen Peroxide
Messina, M. S.*; Quargnali, G.; Chang, C. J.* ACS Bio Med. Chem. Au 2022, DOI: 10.1021/acsbiomedchemau.2c00052
Messina, M. S.*; Quargnali, G.; Chang, C. J.* ACS Bio Med. Chem. Au 2022, DOI: 10.1021/acsbiomedchemau.2c00052
Manuscripts prior to University of Delaware Appointment
*denotes corresponding author; †denotes equal contribution; names of the undergraduate student co-workers are underlined
16.) Organometallic S-arylation Reagents for Rapid PEGylation of Biomolecules
Montgomery, H.; Messina, M. S.; Doud, E.; Spokoyny, A. M.*; Maynard, H. D.* Bioconjugate Chem. 2022, 33, 1536-1542.
15.) A Puromycin-Dependent Activity-Based Sensing Probe for Histochemical Staining of Hydrogen Peroxide in Cells and Animal Tissues
Hoshi, K. †; Messina, M.S. †; Ohata, J.; Chung, C. Y.-S.; Chang, C. J.* Nat. Protoc. 2022, 17, 1691-1710.
14.) A Tandem Activity-Based Sensing and Labeling Strategy Enables Imaging of Transcellular Hydrogen Peroxide Signaling
Iwashita, H.; Castillo, E.; Messina, M. S.; Swanson, R. A.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2021, 118, e2018513118.
13.) Modification of Biomolecules Using Olefin Metathesis
Messina, M. S.; Maynard, H. D.* Mater. Chem. Front. 2020, 4, 1040-1051. Special issue in honor of Professor Robert H. Grubbs for his 50-year contributions in metathesis.
12.) Preparation of Biomolecule-Polymer Conjugates by Grafting-From Using ATRP, RAFT, or ROMP
Messina, M.S.; Messina, K. M. M.; Bhattacharya, A.; Montgomery, H. R.; Maynard, H. D.* Prog. Polym. Sci. 2020, 100, 101186. Special issue celebrating 100 years of polymer science.
11.) Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions
Qian, E. A.; Han, Y.; Messina, M. S.; Maynard, H. D.; Král, P.; Spokoyny, A. M.* Bioconjugate Chem. 2019, 30, 2594-2603.
10.) Electrically Responsive Polymer Brush Grafted Ultrafiltration Membranes
Khor, C. M.; Zhu, X.; Messina, M. S.; Poon, S.; Lew, X. Y.; Maynard, H. D.; Jassby, D.* ACS Materials Lett. 2019, 1, 647-654.
9.) Photooxidative Generation of Dodecaborate-Based Weakly Coordinating Anions
Axtell, J. C.*; Messina, M. S.; Liu, J.-Y.; Galaktionova, D.; Schwan, J.; Porter, T. M.; Savage, M. D.; Wixtrom, A. I.; Rheingold, A. L.; Kubiak, C. P.; Winkler, J. R.; Gray, H. B.*; Král, P.*; Alexandrova, A. N.*; Spokoyny, A. M.* Inorg. Chem. 2019, 58, 10516-10526. Special Issue on Emerging Investigators in Inorganic Chemistry.
8.) Carborane RAFT Agents as Tunable and Functional Molecular Probes for Polymer Materials
Messina, M. S.*; Graefe, C. T.; Chong, P.; Ebrahim, O. M.; Pathuri, R. S.; Bernier, N. A.; Mills, H. A.; Rheingold, A. L.; Frontiera, R. R.*; Maynard, H. D.*; Spokoyny, A. M.* Polym. Chem. 2019, 10, 1660-1667.
7.) Organometallic Gold(III) Reagents for Cysteine Arylation
Messina, M. S.†; Stauber, J. M.†; Waddington, M. A.; Rheingold, A. L.; Maynard, H. D.*; Spokoyny, A. M.* J. Am. Chem. Soc. 2018, 140, 7065-7069.
6.) Effect of Trehalose Polymer Regioisomers on Protein Stabilization
Messina, M. S.†; Ko, J. H.†; Yang, Z.; Strouse, M. J.; Houk, K. N.; Maynard, H. D.* Polym. Chem. 2017, 8, 4781-4788.
Highlighted on the journal front cover.
5.) Cage-Walking: Vertex Differentiation by Palladium-Catalyzed Isomerization of B(9)-Bromo-meta-Carborane
Dziedzic, R. M.; Martin, J. L.; Axtell, J. C.; Saleh, L. M. A.; Ong, T.-C.; Yang, Y.-F.; Messina, M. S.; Rheingold, A. L.; Houk, K. N.; Spokoyny, A. M.* J. Am. Chem. Soc. 2017, 139, 7729-7732.
4.) Atomically Precise Organomimetic Cluster Nanomolecules (OCNs) Assembled via Perfluoroaryl-thiol SNAr chemistry
Qian, E. A.; Wixtrom, A. I.; Axtell, J. C.; Saebi, A.; Jung, D.; Rehak, P.; Han, Y.; Moully, E. H.; Mosallaei, D.; Chow, S.; Messina, M. S.; Wang, J. -Y.; Royappa, A. T.; Rheingold, A. L.; Maynard, H. D.; Král, P.; Spokoyny, A. M.* Nature Chem. 2017, 9, 333-340.
3.) Visible-Light Induced Olefin Activation using 3D Aromatic Boron-Rich Cluster Photooxidants
Messina, M. S.†; Axtell, J. C.†; Wang, Y.; Chong, P.; Wixtrom, A. I.; Kirlikovali, K. O.; Upton, B. M.; Hunter, B. M.; Shafaat, O. S.; Khan, S. I.; Winkler, J. R.; Gray, H. B.; Alexandrova, A. N.; Maynard, H. D.; Spokoyny, A. M.* J. Am. Chem. Soc. 2016, 138, 6952-6955.
Highlighted by Phil Szuromi in Science 2016, 352, 1422-1423; Highlighted by UCLA Chemistry and Biochemistry; Highlighted in C&EN Talented 12 article.
2.) Reversible Morphological Changes of Assembled Supramolecular Amphiphiles Triggered by pH-Modulated Host-Guest Interactions
Olson, M. A.*; Messina, M. S.; Thompson, J. R.; Dawson, T. J.; Goldner, A.; Gaspar, D.; Vazquez, M.; Lehrman, J. A.; Sue, A. C.-H. Org. Biomol. Chem. 2016, 14, 5714-5720. New Talent Issue.
1.) Template-Directed Self-Assembly by way of Molecular Recognition at the Micellar-Solvent Interface: Modulation of the Critical Micelle Concentration
Olson, M. A.*; Thompson, J. R.; Dawson, T. J.; Hernandez, C. M.; Messina, M. S.; O’Neal, T. Org. Biomol. Chem. 2013, 11, 6483-6492.
Highlighted on the journal front cover.
*denotes corresponding author; †denotes equal contribution; names of the undergraduate student co-workers are underlined
16.) Organometallic S-arylation Reagents for Rapid PEGylation of Biomolecules
Montgomery, H.; Messina, M. S.; Doud, E.; Spokoyny, A. M.*; Maynard, H. D.* Bioconjugate Chem. 2022, 33, 1536-1542.
15.) A Puromycin-Dependent Activity-Based Sensing Probe for Histochemical Staining of Hydrogen Peroxide in Cells and Animal Tissues
Hoshi, K. †; Messina, M.S. †; Ohata, J.; Chung, C. Y.-S.; Chang, C. J.* Nat. Protoc. 2022, 17, 1691-1710.
14.) A Tandem Activity-Based Sensing and Labeling Strategy Enables Imaging of Transcellular Hydrogen Peroxide Signaling
Iwashita, H.; Castillo, E.; Messina, M. S.; Swanson, R. A.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2021, 118, e2018513118.
13.) Modification of Biomolecules Using Olefin Metathesis
Messina, M. S.; Maynard, H. D.* Mater. Chem. Front. 2020, 4, 1040-1051. Special issue in honor of Professor Robert H. Grubbs for his 50-year contributions in metathesis.
12.) Preparation of Biomolecule-Polymer Conjugates by Grafting-From Using ATRP, RAFT, or ROMP
Messina, M.S.; Messina, K. M. M.; Bhattacharya, A.; Montgomery, H. R.; Maynard, H. D.* Prog. Polym. Sci. 2020, 100, 101186. Special issue celebrating 100 years of polymer science.
11.) Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions
Qian, E. A.; Han, Y.; Messina, M. S.; Maynard, H. D.; Král, P.; Spokoyny, A. M.* Bioconjugate Chem. 2019, 30, 2594-2603.
10.) Electrically Responsive Polymer Brush Grafted Ultrafiltration Membranes
Khor, C. M.; Zhu, X.; Messina, M. S.; Poon, S.; Lew, X. Y.; Maynard, H. D.; Jassby, D.* ACS Materials Lett. 2019, 1, 647-654.
9.) Photooxidative Generation of Dodecaborate-Based Weakly Coordinating Anions
Axtell, J. C.*; Messina, M. S.; Liu, J.-Y.; Galaktionova, D.; Schwan, J.; Porter, T. M.; Savage, M. D.; Wixtrom, A. I.; Rheingold, A. L.; Kubiak, C. P.; Winkler, J. R.; Gray, H. B.*; Král, P.*; Alexandrova, A. N.*; Spokoyny, A. M.* Inorg. Chem. 2019, 58, 10516-10526. Special Issue on Emerging Investigators in Inorganic Chemistry.
8.) Carborane RAFT Agents as Tunable and Functional Molecular Probes for Polymer Materials
Messina, M. S.*; Graefe, C. T.; Chong, P.; Ebrahim, O. M.; Pathuri, R. S.; Bernier, N. A.; Mills, H. A.; Rheingold, A. L.; Frontiera, R. R.*; Maynard, H. D.*; Spokoyny, A. M.* Polym. Chem. 2019, 10, 1660-1667.
7.) Organometallic Gold(III) Reagents for Cysteine Arylation
Messina, M. S.†; Stauber, J. M.†; Waddington, M. A.; Rheingold, A. L.; Maynard, H. D.*; Spokoyny, A. M.* J. Am. Chem. Soc. 2018, 140, 7065-7069.
6.) Effect of Trehalose Polymer Regioisomers on Protein Stabilization
Messina, M. S.†; Ko, J. H.†; Yang, Z.; Strouse, M. J.; Houk, K. N.; Maynard, H. D.* Polym. Chem. 2017, 8, 4781-4788.
Highlighted on the journal front cover.
5.) Cage-Walking: Vertex Differentiation by Palladium-Catalyzed Isomerization of B(9)-Bromo-meta-Carborane
Dziedzic, R. M.; Martin, J. L.; Axtell, J. C.; Saleh, L. M. A.; Ong, T.-C.; Yang, Y.-F.; Messina, M. S.; Rheingold, A. L.; Houk, K. N.; Spokoyny, A. M.* J. Am. Chem. Soc. 2017, 139, 7729-7732.
4.) Atomically Precise Organomimetic Cluster Nanomolecules (OCNs) Assembled via Perfluoroaryl-thiol SNAr chemistry
Qian, E. A.; Wixtrom, A. I.; Axtell, J. C.; Saebi, A.; Jung, D.; Rehak, P.; Han, Y.; Moully, E. H.; Mosallaei, D.; Chow, S.; Messina, M. S.; Wang, J. -Y.; Royappa, A. T.; Rheingold, A. L.; Maynard, H. D.; Král, P.; Spokoyny, A. M.* Nature Chem. 2017, 9, 333-340.
3.) Visible-Light Induced Olefin Activation using 3D Aromatic Boron-Rich Cluster Photooxidants
Messina, M. S.†; Axtell, J. C.†; Wang, Y.; Chong, P.; Wixtrom, A. I.; Kirlikovali, K. O.; Upton, B. M.; Hunter, B. M.; Shafaat, O. S.; Khan, S. I.; Winkler, J. R.; Gray, H. B.; Alexandrova, A. N.; Maynard, H. D.; Spokoyny, A. M.* J. Am. Chem. Soc. 2016, 138, 6952-6955.
Highlighted by Phil Szuromi in Science 2016, 352, 1422-1423; Highlighted by UCLA Chemistry and Biochemistry; Highlighted in C&EN Talented 12 article.
2.) Reversible Morphological Changes of Assembled Supramolecular Amphiphiles Triggered by pH-Modulated Host-Guest Interactions
Olson, M. A.*; Messina, M. S.; Thompson, J. R.; Dawson, T. J.; Goldner, A.; Gaspar, D.; Vazquez, M.; Lehrman, J. A.; Sue, A. C.-H. Org. Biomol. Chem. 2016, 14, 5714-5720. New Talent Issue.
1.) Template-Directed Self-Assembly by way of Molecular Recognition at the Micellar-Solvent Interface: Modulation of the Critical Micelle Concentration
Olson, M. A.*; Thompson, J. R.; Dawson, T. J.; Hernandez, C. M.; Messina, M. S.; O’Neal, T. Org. Biomol. Chem. 2013, 11, 6483-6492.
Highlighted on the journal front cover.
Patents and Patent Applications
1.) Novel Three-Dimensional Boron-Rich Clusters
Spokoyny, A. M.; Maynard, H. D.; Qian, E.; Messina, M. S.; Wixtrom, A. I.; Axtell, J. C.; Kirlikovali, K. O.; Gonzalez, A. United States Patent: 20190047871A1; International: WO/2017/143348 A2.
1.) Novel Three-Dimensional Boron-Rich Clusters
Spokoyny, A. M.; Maynard, H. D.; Qian, E.; Messina, M. S.; Wixtrom, A. I.; Axtell, J. C.; Kirlikovali, K. O.; Gonzalez, A. United States Patent: 20190047871A1; International: WO/2017/143348 A2.